{"pluginData":{"15300":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"15300","dataValue":{"default":{"theText":"<p>How well can you answer the following questions?</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"7e5ca562-4704-460e-a80f-2d11814ef8b8","revisionUuid":"68aa6e6a-8a49-4908-ac8c-4f4017ca2d90"}],"16199":[{"pluginKey":"divider","typeKey":"content","dataKey":"16199","dataValue":{"default":{"placeholder":null}},"dataVersion":1,"uuid":"837e46c9-fb81-4c1f-8639-1b1186780025","revisionUuid":"bdbc72a0-6368-4823-88ca-a276955bf31f"}],"15304":[{"pluginKey":"select","typeKey":"content","dataKey":"15304","dataValue":{"default":{"question":"<ul><li>What is the structure of skeletal muscle?</li><li>How does an electrical impulse from a nerve lead to muscle contraction?</li><li>How does skeletal muscle contract and generate force?</li><li>What are the different types of skeletal muscle contractions?</li></ul>","multiselect":false,"answers":[{"answer":"<p>I could explain these in detail.</p>"},{"answer":"<p>I could describe the basic processes or principles.</p>"},{"answer":"<p>I could not adequately answer these questions.</p>"}],"singleAttempt":false,"assessmentType":"noAssessment","maximumGrade":1.0}},"dataVersion":2,"uuid":"cc3c5fa1-6216-4721-811f-639ffd645dee","revisionUuid":"c61e6fc1-8360-4185-b38c-9a36ca1673f6"},{"pluginKey":"select","typeKey":"modelAnswer","dataKey":"15304","dataValue":{"default":{"answers":[{"answerDescription":"<p></p>","checked":false},{"answerDescription":"<p></p>","checked":false},{"answerDescription":"<p></p>","checked":false}]}},"dataVersion":1,"uuid":"cc3c5fa1-6216-4721-811f-639ffd645dee","revisionUuid":"c61e6fc1-8360-4185-b38c-9a36ca1673f6"}],"15425":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"15425","dataValue":{"default":{"theText":"<h3>Skeletal muscle function</h3>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"fc4d38ae-abfd-41cb-aa1d-8ca9290d254e","revisionUuid":"718988b5-d146-49ad-83b1-915f60b64bed"}],"16634":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"16634","dataValue":{"default":{"theText":"<p>Example data is shown below of electrical activity (EMG) and force of contraction when the muscle is stimulated two times in close succession. Move through <a data-popupkey=\"19184\" rel=\"nofollow\" target=\"_blank\">records</a> 1–5 to see how EMG and force of contraction changes as the time between the delivery of the two stimuli is reduced.</p><p>Use this data to answer the question that follows.</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"03ec96cc-9596-4910-9621-7aa0d6520af5","revisionUuid":"323b0b0e-2335-432a-8587-66961b0ec6c8"}],"15545":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"15545","dataValue":{"default":{"theText":"<h3>Skeletal muscle structure</h3>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"2243aa0d-4f8a-48fd-bc82-7e9bedf525f7","revisionUuid":"311aa5c8-f861-48d7-a867-c0c5824249ea"}],"16755":[{"pluginKey":"table","typeKey":"content","dataKey":"16755","dataValue":{"default":{"rows":[{"headerRow":true,"columns":[{"cellStyle":"grayCellStyle","content":"<p><strong>Type of Contraction</strong></p>","headerColumn":true,"decimalPlaces":2,"cellFormat":"number"},{"cellStyle":"grayCellStyle","content":"<p><strong>Tension</strong></p>","headerColumn":false,"decimalPlaces":2,"cellFormat":"number"},{"cellStyle":"grayCellStyle","content":"<p><strong>Muscle Length</strong></p>","headerColumn":false,"decimalPlaces":2,"cellFormat":"number"},{"cellStyle":"grayCellStyle","content":"<p><strong>Joint</strong></p>","headerColumn":false,"decimalPlaces":2,"cellFormat":"number"}]},{"headerRow":false,"columns":[{"cellStyle":"defaultCellStyle","content":"<p><a data-popupkey=\"11256\" target=\"_blank\">Isometric</a></p>","headerColumn":true,"decimalPlaces":2,"cellFormat":"number"},{"cellStyle":"defaultCellStyle","content":"<p>Muscle develops tension</p>","headerColumn":false,"decimalPlaces":2,"cellFormat":"number"},{"cellStyle":"defaultCellStyle","content":"<p>Muscle stays the same length during contraction</p>","headerColumn":false,"decimalPlaces":2,"cellFormat":"number"},{"cellStyle":"defaultCellStyle","content":"<p>Joint remains in a fixed position (without movement)</p>","headerColumn":false,"decimalPlaces":2,"cellFormat":"number"}]},{"headerRow":false,"columns":[{"cellStyle":"defaultCellStyle","content":"<p><a data-popupkey=\"11255\" target=\"_blank\">Isotonic</a><br /><br />- <a data-popupkey=\"16795\" target=\"_blank\">Concentric</a></p><p>- <a data-popupkey=\"16796\" target=\"_blank\">Eccentric</a></p>","headerColumn":true,"decimalPlaces":2,"cellFormat":"number"},{"cellStyle":"defaultCellStyle","content":"<p>Muscle tension stays the same</p><p> </p>","headerColumn":false,"decimalPlaces":2,"cellFormat":"number"},{"cellStyle":"defaultCellStyle","content":"<p><br /><br />Muscle shortens</p><p>Muscle lengthens</p>","headerColumn":false,"decimalPlaces":2,"cellFormat":"number"},{"cellStyle":"defaultCellStyle","content":"<p>Contraction results in movement at the joints that the muscle affects</p>","headerColumn":false,"decimalPlaces":2,"cellFormat":"number"}]}],"columnWidths":[0.17612419700214133,0.2574946466809422,0.2607066381156317,0.30567451820128483]}},"dataVersion":2,"uuid":"41303255-f4cb-46d0-83af-39b07bd77bda","revisionUuid":"2d2d1b67-a11f-4483-beb1-fea91bc9d53f"}],"14699":[{"pluginKey":"divider","typeKey":"content","dataKey":"14699","dataValue":{"default":{"placeholder":null}},"dataVersion":1,"uuid":"8346062f-7144-416f-afcd-9b14135ecfa9","revisionUuid":"a0b85f75-ebe6-40fc-af8e-12823e90db8f"}],"14697":[{"pluginKey":"divider","typeKey":"content","dataKey":"14697","dataValue":{"default":{"placeholder":null}},"dataVersion":1,"uuid":"b5298118-b6b0-4cf6-9e84-56360d9b5368","revisionUuid":"f268c555-1b4a-41e6-b4f8-379876731cd3"}],"15422":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"15422","dataValue":{"default":{"theText":"<p>A single skeletal muscle contains many <a data-popupkey=\"17116\" rel=\"nofollow\" target=\"_blank\">muscle fibers</a>. Different components of the skeletal muscle are surrounded by layers of connective tissue: the endomysium, perimysium, and epimysium [<strong><a data-popupkey=\"17297\" rel=\"nofollow\" target=\"_blank\">&#43;</a></strong>].</p><ul><li>Each individual muscle fiber is surrounded by a delicate layer of connective tissue called <a data-popupkey=\"15430\" rel=\"nofollow\" target=\"_blank\">endomysium</a>.</li><li>Muscle fibers are grouped into bundles called fascicles. Each fascicle is surrounded by <a data-popupkey=\"17761\" rel=\"nofollow\" target=\"_blank\">perimysium</a>.</li><li>An entire muscle is surrounded by <a data-popupkey=\"15433\" rel=\"nofollow\" target=\"_blank\">epimysium</a> [<a data-popupkey=\"15449\" rel=\"nofollow\" target=\"_blank\"><strong>&#43;</strong></a>].</li></ul><p>Each skeletal muscle fiber is long (up to 30cm; 12 inches) and <a data-popupkey=\"15796\" rel=\"nofollow\" target=\"_blank\">striated</a> in appearance. The striations in skeletal muscle are a result of many repeating units called <strong>sarcomeres</strong>, which are the functional units of the muscle. Sarcomeres are found in <a data-popupkey=\"17119\" rel=\"nofollow\" target=\"_blank\">myofibrils</a>.</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"1f0b5c61-9130-47f7-9772-08d01d640832","revisionUuid":"1daf5701-481f-4172-aa45-dc4532be8a37"}],"15549":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"15549","dataValue":{"default":{"theText":"<p>Motor units vary greatly in size. A single motor neuron may innervate only a few muscle fibers (small motor unit), or thousands of muscle fibers (large motor unit). A single muscle will often contain motor units of varying sizes, and several motor units may work together to coordinate the movement of a single muscle [<a data-popupkey=\"15555\" rel=\"nofollow\" target=\"_blank\"><strong>&#43;</strong></a>].</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"5631d755-7c79-4bc0-a247-b23f5b345861","revisionUuid":"44ec02da-054c-4da0-874b-bec85c67e304"}],"10894":[{"pluginKey":"page","typeKey":"content","dataKey":"10894","dataValue":{"default":{"title":"Neuromuscular junction","rows":[{"cells":[{"panels":[{"pluginKey":"kcTextArea","dataKey":"15566","panelKey":"15567","columns":11}]},{"panels":[{"pluginKey":"button","dataKey":"16373","panelKey":"16374","columns":1}]}]},{"cells":[{"panels":[{"pluginKey":"divider","dataKey":"15602","panelKey":"15603","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"kcTextArea","dataKey":"15598","panelKey":"15599","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"divider","dataKey":"15600","panelKey":"15601","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"kcTextArea","dataKey":"15604","panelKey":"15605","columns":5}]},{"panels":[{"pluginKey":"image","dataKey":"18643","panelKey":"18644","columns":7}]}]},{"cells":[{"panels":[{"pluginKey":"subpage","dataKey":"15628","panelKey":"15629","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"select","dataKey":"15636","panelKey":"15637","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"drag-and-drop","dataKey":"16257","panelKey":"16258","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"divider","dataKey":"15747","panelKey":"15748","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"kcTextArea","dataKey":"15751","panelKey":"15752","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"select","dataKey":"15753","panelKey":"15754","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"select","dataKey":"15632","panelKey":"15633","columns":12}]}]}]}},"dataVersion":2,"uuid":"f1961257-2e9d-4c95-a502-6489832350bf","revisionUuid":"b6217811-08f5-4d30-921c-5a0259cb6708"}],"15306":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"15306","dataValue":{"default":{"theText":"<p>The questions are based on these <a data-popupkey=\"14812\" rel=\"nofollow\" target=\"_blank\">learning objectives</a>. When you see this symbol [<a data-popupkey=\"16298\" rel=\"nofollow\" target=\"_blank\"><strong>&#43;</strong></a>] select it for supplementary questions.</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"528e1b28-c6bc-4eb6-9ee5-84a3669d96e3","revisionUuid":"7443cd9f-18a1-4586-93b7-dea1ed2e7c8c"}],"15547":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"15547","dataValue":{"default":{"theText":"<p>Muscles contract in response to electrical stimulation (that is, action potentials). Groups of muscle fibers within a muscle are innervated by motor neurons; one motor neuron and all the muscle fibers that it innervates is collectively referred to as a <strong>motor unit</strong>. An action potential in a single<em> </em>motor neuron will cause subsequent activation and contraction of all<em> </em>of the muscle fibers innervated by that motor neuron.</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"0443a440-8446-49b0-b441-9152845c57c7","revisionUuid":"73b5a7d8-3fe1-4fb6-b655-cb0a91cca7ec"}],"18027":[{"pluginKey":"image","typeKey":"content","dataKey":"18027","dataValue":{"default":{"imageResourceKey":"18601","caption":"","cropLeftOffset":0.0,"cropTopOffset":0.0,"cropWidthProportion":1.0,"presentedRatio":1.0,"presentedSize":100.0,"rotationRadians":0.0,"flip":false,"copyrightText":""}},"dataVersion":2,"uuid":"83151116-5897-493c-b9ac-1e7ea5a9e99d","revisionUuid":"a98004fd-2591-4408-8720-f080e5660fc8"}],"15553":[{"pluginKey":"image","typeKey":"content","dataKey":"15553","dataValue":{"default":{"imageResourceKey":"18230","caption":"<p></p>","cropLeftOffset":0.0,"cropTopOffset":0.0,"cropWidthProportion":1.0,"presentedRatio":0.534419337887546,"presentedSize":100.0,"rotationRadians":0.0,"flip":false,"copyrightText":""}},"dataVersion":2,"uuid":"4a928143-701a-41de-bd53-24f25907d05c","revisionUuid":"a4adbaa0-aa59-451a-8506-ab2a497a0ab1"}],"15430":[{"pluginKey":"popupPage","typeKey":"content","dataKey":"15430","dataValue":{"default":{"title":"Endomysium","rows":[],"shortDescription":"<p>The prefix endo- is derived from the Greek word <em>endon</em> meaning &#34;within&#34;. Remember that the <strong>endo</strong>mysium (which surrounds each muscle fiber) lies deepest <strong>within</strong> the muscle.</p>"}},"dataVersion":2,"uuid":"246b8a55-a099-42ec-8b09-80e4348bc98f","revisionUuid":"1957c2cb-e528-42f1-a46d-0c0e2bbdb8d3"}],"15551":[{"pluginKey":"categories","typeKey":"content","dataKey":"15551","dataValue":{"default":{"question":"<p>Which statements regarding motor units are true, and which are false?</p>","labelItems":[{"label":"<p>A motor unit consists of a motor neuron and all the muscle fibers it innervates.</p>"},{"label":"<p>A single muscle fiber may be innervated by two or more motor neurons.</p>"},{"label":"<p>Many muscles contain motor units of different sizes.</p>"}],"categoryItems":[{"title":"<p>True</p>","imageResourceKey":"14175","copyrightText":""},{"title":"<p>False</p>","imageResourceKey":"14176","copyrightText":""}],"singleAttempt":false,"assessmentType":"instantFeedback","maximumGrade":1.0}},"dataVersion":2,"uuid":"04be100c-6515-47e1-a07a-18d7ced4e462","revisionUuid":"42ec7e82-9168-4c97-9c5a-8ce901fa171d"},{"pluginKey":"categories","typeKey":"modelAnswer","dataKey":"15551","dataValue":{"default":{"categoryAnswerItems":[{"labelAnswerItems":[{"labelIndex":0},{"labelIndex":2}]},{"labelAnswerItems":[{"labelIndex":1}]}],"feedbackText":"<p>Mature muscle fibers are only ever innervated by one motor neuron.</p>"}},"dataVersion":2,"uuid":"04be100c-6515-47e1-a07a-18d7ced4e462","revisionUuid":"42ec7e82-9168-4c97-9c5a-8ce901fa171d"}],"17297":[{"pluginKey":"popupPage","typeKey":"content","dataKey":"17297","dataValue":{"default":{"title":"Question: Nerve and muscle similarities","rows":[{"cells":[{"panels":[{"pluginKey":"kcTextArea","dataKey":"19618","panelKey":"19619","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"table","dataKey":"17417","panelKey":"17418","columns":12}]}]}],"shortDescription":"<p>Have you come across similar terms used elsewhere in the body? For example, in a peripheral nerve?</p>"}},"dataVersion":2,"uuid":"310afdcc-24d1-4b40-81bb-75195a0d7f30","revisionUuid":"11fc95f3-7ef4-4f42-84f1-a4c6a2bffeac"}],"12609":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"12609","dataValue":{"default":{"theText":"<p>In the relaxed state, myosin cannot interact with actin due to the presence of <a data-popupkey=\"15845\" rel=\"nofollow\" target=\"_blank\">tropomyosin</a> that blocks the actin binding site. Muscle depolarization results in the release of stored Ca<sup>2&#43; </sup>and some of this Ca<sup>2&#43;</sup> binds to <a data-popupkey=\"17764\" rel=\"nofollow\" target=\"_blank\">troponin</a>. This causes a conformational change in troponin and a consequent shift in the troponin-tropomyosin complex, which exposes the actin binding site. This allows actin and myosin to bind and form crossbridges. </p><p>The release of Ca<sup>2&#43;</sup> provides the link between electrical excitation of muscle, and the mechanical event of cross-bridge formation. This is referred to as &#34;<strong>excitation-contraction coupling</strong>&#34;.</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"bb99d986-570a-48e1-a169-ee0d34fe931e","revisionUuid":"d39816a0-c205-4767-b17f-3fe5deba6b86"}],"12961":[{"pluginKey":"select","typeKey":"content","dataKey":"12961","dataValue":{"default":{"question":"<p>What event precedes the powerstroke action of skeletal muscle contractions?</p>","multiselect":false,"answers":[{"answer":"<p>Attachment of ATP on the myosin head.</p>"},{"answer":"<p>Formation of a crossbridge between the actin and myosin.</p>"},{"answer":"<p>Release of P<sub>i </sub>from the myosin head.</p>"}],"singleAttempt":false,"assessmentType":"instantFeedback","maximumGrade":1.0}},"dataVersion":2,"uuid":"011083b7-3c35-4ec7-b4ed-8e1cae27eca7","revisionUuid":"0fa192e8-983f-4283-b0be-7b5e52f71589"},{"pluginKey":"select","typeKey":"modelAnswer","dataKey":"12961","dataValue":{"default":{"answers":[{"answerDescription":"<p>Attachment of an ATP molecule to the myosin head breaks the link between actin and myosin. </p>","checked":false},{"answerDescription":"<p>While this facilitates the powerstroke action, the attachment of the actin and myosin molecules does not cause the movement itself. This action requires energy supplied by the release of another molecule.</p>","checked":false},{"answerDescription":"<p>The release of P<sub>i</sub><em> </em>provides the energy needed for the myosin head to pull on the actin filament and initiates a powerstroke.</p>","checked":true}]}},"dataVersion":1,"uuid":"011083b7-3c35-4ec7-b4ed-8e1cae27eca7","revisionUuid":"0fa192e8-983f-4283-b0be-7b5e52f71589"}],"15556":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"15556","dataValue":{"default":{"theText":"<p><strong>What kinds of movements do you think would result from the activation of smaller and larger motor units?</strong></p><p>The smaller the motor unit, the finer the control of movement in that muscle. Muscles that control the movement of the fingers and eyes are innervated by small motor units, which allow for fine motor control (small movements). In comparison, motor units that control larger limb muscles may be much larger in size.</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"6b704d22-9905-4ac1-b7c2-2ef3df1523ef","revisionUuid":"5db787dd-2a0e-486c-80f8-a9271be19fb0"}],"18705":[{"pluginKey":"whitespace","typeKey":"content","dataKey":"18705","dataValue":{"default":{"height":30}},"dataVersion":1,"uuid":"b19db2c4-c129-485b-9907-786f60582a4c","revisionUuid":"1ddcb681-0a81-4894-9eaf-bf1fc3678dba"}],"15555":[{"pluginKey":"popupPage","typeKey":"content","dataKey":"15555","dataValue":{"default":{"title":"Question: Motor unit size","rows":[{"cells":[{"panels":[{"pluginKey":"kcTextArea","dataKey":"15556","panelKey":"15557","columns":12}]}]}],"shortDescription":"<p>What kinds of movements do you think would result from the activation of smaller and larger motor units?</p>"}},"dataVersion":2,"uuid":"59294e63-5128-49ea-91f0-9c99d5aeb51c","revisionUuid":"4322f7bd-764b-43bb-82b2-385fd1434c5f"}],"16402":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"16402","dataValue":{"default":{"theText":"<h3>Do you want a challenge?</h3><p>Below are five short-answer questions based on the <a data-popupkey=\"14812\" rel=\"nofollow\" target=\"_blank\">learning objectives</a> for you to practice answering. Alternatively, try explaining the answers out loud or to your friends or family. </p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"5c1a82dd-fcd7-465c-9bb3-69a2530b9ae3","revisionUuid":"a8833dff-d34a-46e5-ac10-11329634af8a"}],"15796":[{"pluginKey":"popupPage","typeKey":"content","dataKey":"15796","dataValue":{"default":{"title":"Striated","rows":[],"shortDescription":"<p>Striated means striped with light and dark colored bands, perpendicular to the long axis of muscle fibers.</p>"}},"dataVersion":2,"uuid":"b2b68688-4b9d-43a8-ba5e-80750289d4e7","revisionUuid":"0fea4250-d403-4f67-942a-937f421cb131"}],"15433":[{"pluginKey":"popupPage","typeKey":"content","dataKey":"15433","dataValue":{"default":{"title":"Epimysium","rows":[],"shortDescription":"<p>The prefix epi- is derived from the Greek word <em>epi</em> meaning &#34;above&#34; or &#34;over&#34;. Remember that the epimysium is the <strong>outermost</strong> layer which surrounds the whole muscle.</p>"}},"dataVersion":2,"uuid":"67234f21-ebdb-4a5e-a618-3574790c9d03","revisionUuid":"dd2fb2e8-8b05-4de4-95c7-431b16dd8a17"}],"16529":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"16529","dataValue":{"default":{"theText":"<p>Step 2: <strong>ATP hydrolysis; myosin head becomes “cocked”</strong>. The enzyme ATPase hydrolyzes (breaks down) ATP to <a data-popupkey=\"17124\" rel=\"nofollow\" target=\"_blank\">ADP</a> and <a data-popupkey=\"17125\" rel=\"nofollow\" target=\"_blank\">P<sub>i</sub></a>, but ADP and P<sub>i</sub> remain attached to myosin. The myosin head rotates to a &#34;cocked&#34; position so that it is aligned with a new actin binding site (further along the actin filament) [<a data-popupkey=\"15924\" rel=\"nofollow\" target=\"_blank\"><strong>&#43;</strong></a>].</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"cf1d3c85-6552-4329-b662-bb26bb10375b","revisionUuid":"6c528328-9f5d-4ded-a406-6c88356d64bf"}],"16406":[{"pluginKey":"subpage","typeKey":"content","dataKey":"16406","dataValue":{"default":{"subpages":[{"rows":[{"cells":[{"panels":[{"pluginKey":"text-question","dataKey":"16962","panelKey":"16963","columns":12}]}]}]},{"rows":[{"cells":[{"panels":[{"pluginKey":"text-question","dataKey":"16956","panelKey":"16957","columns":12}]}]}]},{"rows":[{"cells":[{"panels":[{"pluginKey":"text-question","dataKey":"16970","panelKey":"16971","columns":12}]}]}]},{"rows":[{"cells":[{"panels":[{"pluginKey":"text-question","dataKey":"17014","panelKey":"17015","columns":12}]}]}]},{"rows":[{"cells":[{"panels":[{"pluginKey":"text-question","dataKey":"17012","panelKey":"17013","columns":12}]}]}]}]}},"dataVersion":3,"uuid":"187ab468-18f8-4a85-9789-9c0fdcb339aa","revisionUuid":"50193dec-ea52-4680-97d1-e8d225ee4f54"}],"18599":[{"pluginKey":"whitespace","typeKey":"content","dataKey":"18599","dataValue":{"default":{"height":30}},"dataVersion":1,"uuid":"52946db0-7cb2-44eb-9e83-a274580896f0","revisionUuid":"b4051096-6a0a-4b09-bf82-ccafa1b252d6"}],"19320":[{"pluginKey":"image","typeKey":"content","dataKey":"19320","dataValue":{"default":{"imageResourceKey":"19322","caption":"","cropLeftOffset":0.0,"cropTopOffset":7.57840092582798,"cropWidthProportion":0.9227636490424348,"presentedRatio":0.652147963848323,"presentedSize":90.23792833037233,"rotationRadians":0.0,"flip":false,"copyrightText":""}},"dataVersion":2,"uuid":"a7147557-6104-4390-a2c8-b7382adc1fcc","revisionUuid":"fc5baedb-02ee-4929-b48e-6b865a9ac187"}],"15761":[{"pluginKey":"divider","typeKey":"content","dataKey":"15761","dataValue":{"default":{"placeholder":null}},"dataVersion":1,"uuid":"61e213bd-ca67-4e81-9720-74ce7d2b9a32","revisionUuid":"8189c47e-1f72-4de9-b6b7-052b4561c2ed"}],"16971":[{"pluginKey":"text-question","typeKey":"presentation","dataKey":"16971","dataValue":{"height":100},"dataVersion":3,"uuid":"afd9aa56-4475-4fbe-8f8f-b121d67b4150","revisionUuid":"a716e6c3-f094-4a8f-9042-ee5ed39c527d"}],"16970":[{"pluginKey":"text-question","typeKey":"gradingContent","dataKey":"16970","dataValue":{"default":{"gradingInstructions":"<p></p>"}},"dataVersion":1,"uuid":"846f4beb-970b-47c4-b811-ee206b6cd06c","revisionUuid":"24781738-1a4e-40ea-8ae1-e207a1a846af"},{"pluginKey":"text-question","typeKey":"modelAnswer","dataKey":"16970","dataValue":{"default":{"answer":"<p>1. ATP binds; actin and myosin link is broken; an ATP molecule attaches to the myosin head and breaks the link between actin and myosin.</p><p>2. ATP hydrolysis; myosin head becomes “cocked”; The enzyme ATPase hydrolyzes (breaks down) ATP to ADP and Pi, but ADP and Pi remain attached to myosin. The myosin head rotates to a &#34;cocked&#34; position so that it is aligned with a new actin binding site (further along the actin filament).</p><p>3. Pi dissociates from myosin; new crossbridge forms; Pi dissociates from the myosin head and allows myosin to bind with high affinity to actin; a new crossbridge is formed.</p><p>4. Powerstroke occurs; muscle shortens; The myosin neck rotates around the myosin head which is attached to actin. This bending action results in a &#34;powerstroke&#34; where myosin pulls actin closer to the center of the sarcomere. The muscle shortens and force is generated in the muscle.</p><p>5. ADP dissociates from myosin; myosin awaits another ATP molecule; ADP dissociates from myosin, but actin and myosin remain attached and in a rigid state. Another ATP molecule is required to break the link between actin and myosin, and for another crossbridge cycle to start.</p>"}},"dataVersion":2,"uuid":"846f4beb-970b-47c4-b811-ee206b6cd06c","revisionUuid":"24781738-1a4e-40ea-8ae1-e207a1a846af"},{"pluginKey":"text-question","typeKey":"content","dataKey":"16970","dataValue":{"default":{"question":"<p>What is the sequence of events for one complete crossbridge cycle?</p>","singleAttempt":false,"assessmentType":"instantFeedback","maximumGrade":1.0}},"dataVersion":4,"uuid":"846f4beb-970b-47c4-b811-ee206b6cd06c","revisionUuid":"24781738-1a4e-40ea-8ae1-e207a1a846af"}],"16299":[{"pluginKey":"categories","typeKey":"modelAnswer","dataKey":"16299","dataValue":{"default":{"categoryAnswerItems":[{"labelAnswerItems":[{"labelIndex":5},{"labelIndex":3},{"labelIndex":0},{"labelIndex":4}]},{"labelAnswerItems":[{"labelIndex":2},{"labelIndex":1}]}],"feedbackText":""}},"dataVersion":2,"uuid":"024f87a5-f76f-437e-8e7b-2f8dc76b0524","revisionUuid":"e384ded4-ba77-4d4d-a382-145f04e7e038"},{"pluginKey":"categories","typeKey":"content","dataKey":"16299","dataValue":{"default":{"question":"<p><strong>What are some effective ways to study?</strong></p><p>When you select a [<strong>&#43;</strong>], you will be asked questions that require you to <strong>recall</strong> information, <strong>relate</strong> a concept to something you already know, or <strong>reflect</strong> on the topic in a new way. 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How do they differ?</p>","singleAttempt":false,"assessmentType":"instantFeedback","maximumGrade":1.0}},"dataVersion":4,"uuid":"c6e85fb9-56c9-49bc-ad18-b285ab2239f7","revisionUuid":"18162c99-e46d-4b32-b5d3-71755e9119db"},{"pluginKey":"text-question","typeKey":"gradingContent","dataKey":"16611","dataValue":{"default":{"gradingInstructions":"<p></p>"}},"dataVersion":1,"uuid":"c6e85fb9-56c9-49bc-ad18-b285ab2239f7","revisionUuid":"18162c99-e46d-4b32-b5d3-71755e9119db"},{"pluginKey":"text-question","typeKey":"modelAnswer","dataKey":"16611","dataValue":{"default":{"answer":"<p>EMG lasts only a short period of time, while the force of muscle contraction (muscle tension) lasts much longer. </p>"}},"dataVersion":2,"uuid":"c6e85fb9-56c9-49bc-ad18-b285ab2239f7","revisionUuid":"18162c99-e46d-4b32-b5d3-71755e9119db"}],"14796":[{"pluginKey":"select","typeKey":"content","dataKey":"14796","dataValue":{"default":{"question":"<p>Which statement regarding muscle twitch is true?</p>","multiselect":true,"answers":[{"answer":"<p>Following maximal nerve stimulation, it represents the greatest force that the stimulated muscle can produce.</p>"},{"answer":"<p>It is only seen following peripheral nerve stimulation.</p>"},{"answer":"<p>It is the normal type of contraction in a functioning skeletal muscle.</p>"}],"singleAttempt":false,"assessmentType":"instantFeedback","maximumGrade":1.0}},"dataVersion":2,"uuid":"db9402a3-2fae-4c40-8329-5fd891348684","revisionUuid":"9dfc04ee-4b1b-4491-becb-aad572a39f1d"},{"pluginKey":"select","typeKey":"modelAnswer","dataKey":"14796","dataValue":{"default":{"answers":[{"answerDescription":"<p>A single muscle twitch is the smallest force that a stimulated muscle can produce. </p>","checked":false},{"answerDescription":"<p>Twitches result from an action potential that travels along the peripheral nerve and is transmitted across the NMJ into the muscle fiber. </p>","checked":true},{"answerDescription":"<p>Normal muscle function is stimulated by multiple action potentials, which causes a summative response. 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It requires the presence of Ca<sup>2&#43;</sup> and energy in the form of <a data-popupkey=\"17123\" rel=\"nofollow\" target=\"_blank\">adenosine triphosphate</a> (ATP).</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"2bc5813c-6228-433e-8899-4053831a9dd3","revisionUuid":"f27f5984-c963-48fe-bd48-61c10834513b"}],"16617":[{"pluginKey":"select","typeKey":"modelAnswer","dataKey":"16617","dataValue":{"default":{"answers":[{"answerDescription":"<p>Frequency refers to the number of action potentials delivered to a muscle within a set period of time. In the data above the muscle is stimulated only once, so frequency remains unchanged.</p>","checked":false},{"answerDescription":"<p>Frequency refers to the number of action potentials delivered to a muscle within a set period of time. 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As ACh binds, the <a data-popupkey=\"15716\" rel=\"nofollow\" target=\"_blank\">ion-channel</a> within the receptor opens and allows sodium ions (Na<sup>&#43;</sup>) ions to flow into the muscle fiber.</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"69fa41d7-f142-4fc3-bf4c-a22b5269306b","revisionUuid":"814fbb87-21bb-46c4-9ae4-4553a2516476"}],"15983":[{"pluginKey":"page","typeKey":"content","dataKey":"15983","dataValue":{"default":{"title":"Sliding filament 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length remains unchanged in <strong>isometric</strong> contractions.</p>","checked":false},{"answerDescription":"<p>Isotonic contractions can be concentric (shortening) or eccentric (lengthening). </p>","checked":true},{"answerDescription":"<p>What do the terms concentric and eccentric mean?</p>","checked":false},{"answerDescription":"<p>What do the terms concentric and eccentric mean?</p>","checked":false}]}},"dataVersion":1,"uuid":"a8c46d07-d644-41e1-873b-05f212a68b2d","revisionUuid":"26f101f5-f98b-47ec-a441-bec0d05c4f0d"},{"pluginKey":"select","typeKey":"content","dataKey":"10056","dataValue":{"default":{"question":"<p>What occurs during an isotonic<em> </em>contraction?</p>","multiselect":false,"answers":[{"answer":"<p>Muscle length is unchanged</p>"},{"answer":"<p>Muscle may either lengthen or shorten</p>"},{"answer":"<p>Muscle only lengthens</p>"},{"answer":"<p>Muscle only 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It involves the L-type Ca<sup>2&#43;</sup> channels in t-tubules and RyRs in the sarcoplasmic reticulum.</p>"}},"dataVersion":2,"uuid":"6abae237-3f30-4b8e-89cb-cbcacb61d34e","revisionUuid":"f033449b-6174-49ef-90ef-89d1804e8bb4"},{"pluginKey":"text-question","typeKey":"content","dataKey":"16956","dataValue":{"default":{"question":"<p>What is excitation-contraction coupling?</p>","singleAttempt":false,"assessmentType":"instantFeedback","maximumGrade":1.0}},"dataVersion":4,"uuid":"6abae237-3f30-4b8e-89cb-cbcacb61d34e","revisionUuid":"f033449b-6174-49ef-90ef-89d1804e8bb4"},{"pluginKey":"text-question","typeKey":"gradingContent","dataKey":"16956","dataValue":{"default":{"gradingInstructions":"<p></p>"}},"dataVersion":1,"uuid":"6abae237-3f30-4b8e-89cb-cbcacb61d34e","revisionUuid":"f033449b-6174-49ef-90ef-89d1804e8bb4"}],"14656":[{"pluginKey":"text-question","typeKey":"gradingContent","dataKey":"14656","dataValue":{"default":{"gradingInstructions":"<p></p>"}},"dataVersion":1,"uuid":"0fc284f4-cbc3-4948-ae2e-d1cc24ab1490","revisionUuid":"0ba914e1-1af8-4b43-b4c1-5fd2b76b4291"},{"pluginKey":"text-question","typeKey":"content","dataKey":"14656","dataValue":{"default":{"question":"<p>What did you find most challenging in this lesson?</p>","singleAttempt":false,"assessmentType":"noAssessment","maximumGrade":1.0}},"dataVersion":4,"uuid":"0fc284f4-cbc3-4948-ae2e-d1cc24ab1490","revisionUuid":"0ba914e1-1af8-4b43-b4c1-5fd2b76b4291"},{"pluginKey":"text-question","typeKey":"modelAnswer","dataKey":"14656","dataValue":{"default":{"answer":""}},"dataVersion":2,"uuid":"0fc284f4-cbc3-4948-ae2e-d1cc24ab1490","revisionUuid":"0ba914e1-1af8-4b43-b4c1-5fd2b76b4291"}],"15988":[{"pluginKey":"select","typeKey":"modelAnswer","dataKey":"15988","dataValue":{"default":{"answers":[{"answerDescription":"<p>While cross bridge formation and breaking occurs rapidly, but this is not the reason why muscle contraction is smooth.</p>","checked":false},{"answerDescription":"<p>This means that the muscle can maintain tension during the contraction, and the contraction is smooth.</p>","checked":true},{"answerDescription":"<p>This is a true statement, but this does not explain why muscle contraction is smooth. </p>","checked":false}]}},"dataVersion":1,"uuid":"9b307bcf-197e-4c0a-88d8-6a9ab1be18b5","revisionUuid":"0fac1435-2100-4ac6-82ff-003f11b50fa8"},{"pluginKey":"select","typeKey":"content","dataKey":"15988","dataValue":{"default":{"question":"<p>Why does the muscle not constantly shorten and lengthen as crossbridges bind and unbind during a muscle contraction? 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The muscle fiber has not completely relaxed in between stimuli, and the second contraction is therefore stronger than normal.</p><p><strong>Incomplete tetanus</strong> (also called unfused tetanus) occurs if stimulation frequency is high, but at a rate that still allows partial relaxation of muscle between twitches.</p><p>At even higher stimulation frequencies, the muscle has no time to relax between successive stimuli. The result is a smooth contraction much stronger than a single twitch: a <strong>tetanic contraction</strong>. The muscle is now said to be in a state of &#34;tetanus&#34;.</p>"}},"dataVersion":2,"uuid":"89cb1609-4256-4174-b87a-2fcb75a92abe","revisionUuid":"4b323e25-23eb-49bc-bf57-8cf7a64bb39c"}],"17254":[{"pluginKey":"select","typeKey":"modelAnswer","dataKey":"17254","dataValue":{"default":{"answers":[{"answerDescription":"<p>Motor units that control larger groups of muscles (like those needed for posture) are generally much larger in size.</p>","checked":true},{"answerDescription":"<p>Motor units that control larger groups of muscles (like those needed for posture) are generally much larger in size.</p>","checked":false}]}},"dataVersion":1,"uuid":"3a59e368-7e66-403e-b743-ae4ff9e4ad1d","revisionUuid":"bc21088f-c571-4f82-9a5a-2075008622a1"},{"pluginKey":"select","typeKey":"content","dataKey":"17254","dataValue":{"default":{"question":"<p>What size are the motor units that control Steve&#39;s postural muscles as he sits at the piano?</p>","multiselect":false,"answers":[{"answer":"<p>Large </p>"},{"answer":"<p>Small </p>"}],"singleAttempt":false,"assessmentType":"instantFeedback","maximumGrade":1.0}},"dataVersion":2,"uuid":"3a59e368-7e66-403e-b743-ae4ff9e4ad1d","revisionUuid":"bc21088f-c571-4f82-9a5a-2075008622a1"}],"16964":[{"pluginKey":"divider","typeKey":"content","dataKey":"16964","dataValue":{"default":{"placeholder":null}},"dataVersion":1,"uuid":"3339a30b-0ec8-4a50-9acf-5b23dec2dd0c","revisionUuid":"eb476aba-af8a-4588-aaba-181a9b97eec2"}],"15753":[{"pluginKey":"select","typeKey":"content","dataKey":"15753","dataValue":{"default":{"question":"<p>ACh must be cleared from the synaptic cleft quickly after it is released, to prevent constant muscle stimulation. How is ACh cleared quickly from the synaptic cleft? </p>","multiselect":false,"answers":[{"answer":"<p>It is broken down by an enzyme and recycled back into vesicles in the synaptic terminal.</p>"},{"answer":"<p>It is taken up by the muscle when it attaches to receptors on the motor endplate.</p>"},{"answer":"<p>It slowly diffuses away from the synaptic cleft.</p>"}],"singleAttempt":false,"assessmentType":"instantFeedback","maximumGrade":1.0}},"dataVersion":2,"uuid":"4c9de99a-1de9-49b6-af4b-1dba86f38ff0","revisionUuid":"3cba3f93-1f3d-4d6f-b03a-a1076a6fab64"},{"pluginKey":"select","typeKey":"modelAnswer","dataKey":"15753","dataValue":{"default":{"answers":[{"answerDescription":"<p>The enzyme acetylcholinesterase (AChE) hydrolyzes (breaks down) ACh into acetate and choline, and some ACh diffuses away from the synaptic cleft. Together, this terminates motor endplate depolarization. Choline is taken up at the synaptic terminal to be recycled in the synthesis of more ACh.</p>","checked":true},{"answerDescription":"<p>ACh is not taken up by muscle after it binds to receptors on the motor endplate.</p>","checked":false},{"answerDescription":"<p>Some ACh diffuses away from the synaptic cleft, but there is another much more important mechanism that helps to clear the neurotransmitter quickly. </p>","checked":false}]}},"dataVersion":1,"uuid":"4c9de99a-1de9-49b6-af4b-1dba86f38ff0","revisionUuid":"3cba3f93-1f3d-4d6f-b03a-a1076a6fab64"}],"15632":[{"pluginKey":"select","typeKey":"modelAnswer","dataKey":"15632","dataValue":{"default":{"answers":[{"answerDescription":"<p>An inhibitor stops the function of the enzyme. In this case, the hydrolyzation of ACh by AChE terminates the muscle contraction. If this activity is inhibited, ACh will remain in the synaptic cleft and the muscle will continue to contract.</p>","checked":false},{"answerDescription":"<p>The presence of an AChE inhibitor impedes the breakdown of ACh, which results in the prolonged presence of ACh in the synaptic cleft. 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Starting with depolarization of the motor endplate, describe the sequence of events that lead to the crossbridge cycle.</p>","singleAttempt":false,"assessmentType":"instantFeedback","maximumGrade":1.0}},"dataVersion":4,"uuid":"822ca2f0-0128-419c-a607-5d45ae8b9631","revisionUuid":"be2fa790-193a-4b3d-b602-b2353671cfca"},{"pluginKey":"text-question","typeKey":"modelAnswer","dataKey":"16962","dataValue":{"default":{"answer":"<p>Local depolarization of the motor endplate leads to initiation of an action potential that spreads along the sarcolemma (muscle fiber membrane) and down t-tubules. This depolarization causes a conformational change in L-type (voltage-sensitive) Ca<sup>2&#43;</sup> channels, which leads to opening of Ca<sup>2&#43;</sup> release channels (RyRs) in the SR. As a consequence, Ca<sup>2&#43;</sup> is released from the SR and Ca<sup>2&#43;</sup> concentration in the muscle fiber increases. Ca<sup>2&#43;</sup> can now bind the troponin-tropomyosin complex, which exposes the actin binding site and allows actin and myosin to bind and form crossbridges.</p>"}},"dataVersion":2,"uuid":"822ca2f0-0128-419c-a607-5d45ae8b9631","revisionUuid":"be2fa790-193a-4b3d-b602-b2353671cfca"},{"pluginKey":"text-question","typeKey":"gradingContent","dataKey":"16962","dataValue":{"default":{"gradingInstructions":"<p></p>"}},"dataVersion":1,"uuid":"822ca2f0-0128-419c-a607-5d45ae8b9631","revisionUuid":"be2fa790-193a-4b3d-b602-b2353671cfca"}],"14785":[{"pluginKey":"divider","typeKey":"content","dataKey":"14785","dataValue":{"default":{"placeholder":null}},"dataVersion":1,"uuid":"4f4a2e9e-561b-4697-b37b-bc021363d01b","revisionUuid":"db4e6abf-1715-4cb6-b19b-ac3721b80ed5"}],"15759":[{"pluginKey":"divider","typeKey":"content","dataKey":"15759","dataValue":{"default":{"placeholder":null}},"dataVersion":1,"uuid":"cb3382a9-e889-4f98-9191-e97119038659","revisionUuid":"59cbb95b-243f-4ec8-9a0f-dc15239d36b7"}],"17259":[{"pluginKey":"divider","typeKey":"content","dataKey":"17259","dataValue":{"default":{"placeholder":null}},"dataVersion":1,"uuid":"4e34230d-9716-4d8a-bc9d-0433ccb3a8da","revisionUuid":"38d68dff-0caa-4c83-a7f5-4b59737c0d34"}],"16968":[{"pluginKey":"categories","typeKey":"content","dataKey":"16968","dataValue":{"default":{"question":"<p>Which statements regarding the crossbridge cycle are true, and which are false?</p>","labelItems":[{"label":"<p>ATP breaks the link between actin and myosin.</p>"},{"label":"<p>Crossbridges continue to form as long as there is sufficient Ca<sup>2&#43;</sup> and ATP is hydrolysed.</p>"},{"label":"<p>Dissociation of Pi away from myosin allows myosin and actin to bind with strength.</p>"},{"label":"<p>Muscle contraction itself is shaky due to the powerstroke action of myosin.</p>"},{"label":"<p>Muscle contraction requires Ca<sup>2&#43;</sup> and ATP.</p>"},{"label":"<p>Muscle filaments shorten as the muscle contracts.</p>"},{"label":"<p>With each powerstroke, myosin pulls actin further away from the center of the sarcomere.</p>"}],"categoryItems":[{"title":"<p>True</p>","imageResourceKey":"","copyrightText":""},{"title":"<p>False</p>","imageResourceKey":"","copyrightText":""}],"singleAttempt":false,"assessmentType":"instantFeedback","maximumGrade":1.0}},"dataVersion":2,"uuid":"51a1e8e4-ed8e-4fff-aebc-3a5604ce7f2b","revisionUuid":"0f12f776-47dd-49be-abcd-1f3422da3f76"},{"pluginKey":"categories","typeKey":"modelAnswer","dataKey":"16968","dataValue":{"default":{"categoryAnswerItems":[{"labelAnswerItems":[{"labelIndex":0},{"labelIndex":1},{"labelIndex":2},{"labelIndex":4}]},{"labelAnswerItems":[{"labelIndex":3},{"labelIndex":5},{"labelIndex":6}]}],"feedbackText":"<p></p>"}},"dataVersion":2,"uuid":"51a1e8e4-ed8e-4fff-aebc-3a5604ce7f2b","revisionUuid":"0f12f776-47dd-49be-abcd-1f3422da3f76"}],"15757":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"15757","dataValue":{"default":{"theText":"<h1>Fibers, fibrils, and sarcomeres</h1>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"395c2e2b-8213-42bb-8dbd-c5137784710d","revisionUuid":"1f6cc846-92ff-4f62-b37b-2c3d1cb7e100"}],"15636":[{"pluginKey":"select","typeKey":"content","dataKey":"15636","dataValue":{"default":{"question":"<p>What is a NMJ?</p>","multiselect":false,"answers":[{"answer":"<p>A chemical synapse between a motor neuron and a muscle fiber.</p>"},{"answer":"<p>An electrical synapse between a motor unit and a muscle.</p>"},{"answer":"<p>Transmission of an electrical impulse to skeletal muscle fibers.</p>"}],"singleAttempt":false,"assessmentType":"instantFeedback","maximumGrade":1.0}},"dataVersion":2,"uuid":"046f94e8-6bc7-4dd4-bf56-f2152566a312","revisionUuid":"98b7237e-d649-41ce-b6c1-3886e6785fe6"},{"pluginKey":"select","typeKey":"modelAnswer","dataKey":"15636","dataValue":{"default":{"answers":[{"answerDescription":"<p>A neuromuscular junction (NMJ) is the chemical synapse between a motor neuron and a muscle fiber. </p>","checked":true},{"answerDescription":"<p>A motor unit is a motor neuron and all muscle fibers it innervates. There are many NMJs within a motor unit.</p>","checked":false},{"answerDescription":"<p>The NMJ is the space between a motor neuron and one of its associated muscle fibers. Transmission occurs across this space.</p>","checked":false}]}},"dataVersion":1,"uuid":"046f94e8-6bc7-4dd4-bf56-f2152566a312","revisionUuid":"98b7237e-d649-41ce-b6c1-3886e6785fe6"}],"15998":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"15998","dataValue":{"default":{"theText":"<p>The formation and breakdown of crossbridges allows actin filaments to slide over myosin and the muscle shortens. This is called the <strong>sliding filament theory</strong>. When nerve impulses to the muscle stop and Ca<sup>2&#43;</sup> is removed by reuptake into the SR, the troponin-tropomyosin complex prevents the interaction of actin and myosin. Crossbridges can no longer form and the muscle relaxes.</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"b601d7f1-4a6f-43dc-bb03-f6d30c593a2c","revisionUuid":"19a31398-ab6d-47b6-9f91-684874894331"}],"18553":[{"pluginKey":"whitespace","typeKey":"content","dataKey":"18553","dataValue":{"default":{"height":44}},"dataVersion":1,"uuid":"d9cfd577-1ba5-400a-8009-47036b4cdfc2","revisionUuid":"02726145-4607-46cf-b099-fcef049d4a53"}],"16011":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"16011","dataValue":{"default":{"theText":"<p><strong>What is the crossbridge cycle and how does this allow muscle contraction?</strong></p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"c31a42ba-41a1-4bf7-b002-72b1356c7d41","revisionUuid":"75923f8c-0e0a-425e-8af5-c263b176808a"}],"16494":[{"pluginKey":"popupPage","typeKey":"content","dataKey":"16494","dataValue":{"default":{"title":"Sarcoplasm","rows":[],"shortDescription":"The sarcoplasm is the cytoplasm of a muscle fiber."}},"dataVersion":2,"uuid":"17e5f83d-f0d0-4c31-9c6c-1306213743ff","revisionUuid":"3af469ab-dcf7-40c9-afe9-5549293c4347"}],"16373":[{"pluginKey":"button","typeKey":"content","dataKey":"16373","dataValue":{"default":{"buttonType":"popup","fileResourceKey":null,"fileType":null,"imageResourceKey":"10560","caption":"<p></p>","popupKey":"16352","presentedRatio":1.0,"presentedSize":85.71428571428571}},"dataVersion":2,"uuid":"73fa9ba4-9563-4ad1-ad26-6cf6212e7c20","revisionUuid":"1cd24dfa-524c-459d-81bb-e951dd04da32"}],"18555":[{"pluginKey":"divider","typeKey":"content","dataKey":"18555","dataValue":{"default":{"placeholder":null}},"dataVersion":1,"uuid":"5e8d6004-565e-4041-831f-4d3b2485ca26","revisionUuid":"edaaec59-cc58-4319-a546-73d6a4384fe9"}],"16371":[{"pluginKey":"button","typeKey":"content","dataKey":"16371","dataValue":{"default":{"buttonType":"popup","fileResourceKey":null,"fileType":null,"imageResourceKey":"10560","caption":"<p></p>","popupKey":"16352","presentedRatio":1.0,"presentedSize":85.71428571428571}},"dataVersion":2,"uuid":"ae7efba7-65ff-44b0-a5dd-623d3c5a0acb","revisionUuid":"5599083f-3caa-4821-917d-b7adbacf9e8a"}],"16492":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"16492","dataValue":{"default":{"theText":"<h3>T-tubules</h3><p>T-tubules (or transverse tubules) are extensions of the muscle membrane that extend into the center of the muscle fiber. They are named so because they lie at right angles to the long axis of the muscle membrane.</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"dffa765d-7878-471a-97a5-d546e5ce9e66","revisionUuid":"fd0af429-e825-4b74-acc4-8ebd9f84ef3f"}],"16015":[{"pluginKey":"table-question","typeKey":"content","dataKey":"16015","dataValue":{"default":{"question":"<p>Complete the table to explain how each factor changes from a muscle that is relaxed to one that is stretched or contracted.</p>","rows":[{"headerRow":true,"columns":[{"cellStyle":"grayCellStyle","content":"<p><strong>Factor</strong></p>","headerColumn":true,"readOnly":true,"decimalPlaces":2,"cellFormat":"number"},{"cellStyle":"grayCellStyle","content":"<p><strong>Stretched Muscle</strong></p>","headerColumn":false,"readOnly":true,"decimalPlaces":2,"cellFormat":"number"},{"cellStyle":"grayCellStyle","content":"<p><strong>Relaxed Muscle</strong></p>","headerColumn":false,"readOnly":true,"decimalPlaces":2,"cellFormat":"number"},{"cellStyle":"grayCellStyle","content":"<p><strong>Contracted Muscle</strong></p>","headerColumn":false,"readOnly":true,"decimalPlaces":2,"cellFormat":"number"}]},{"headerRow":false,"columns":[{"cellStyle":"defaultCellStyle","content":"<p>Extent of filament overlap</p>","headerColumn":true,"readOnly":true,"decimalPlaces":2,"cellFormat":"number"},{"cellStyle":"defaultCellStyle","content":"<p></p>","headerColumn":false,"readOnly":false,"decimalPlaces":2,"cellFormat":"number"},{"cellStyle":"defaultCellStyle","content":"<p>Some overlap</p>","headerColumn":false,"readOnly":true,"decimalPlaces":2,"cellFormat":"number"},{"cellStyle":"defaultCellStyle","content":"<p></p>","headerColumn":false,"readOnly":false,"decimalPlaces":2,"cellFormat":"number"}]},{"headerRow":false,"columns":[{"cellStyle":"defaultCellStyle","content":"<p>Number of crossbridges </p>","headerColumn":true,"readOnly":true,"decimalPlaces":2,"cellFormat":"number"},{"cellStyle":"defaultCellStyle","content":"<p></p>","headerColumn":false,"readOnly":false,"decimalPlaces":2,"cellFormat":"number"},{"cellStyle":"defaultCellStyle","content":"<p>No crossbridges attached</p>","headerColumn":false,"readOnly":true,"decimalPlaces":2,"cellFormat":"number"},{"cellStyle":"defaultCellStyle","content":"<p></p>","headerColumn":false,"readOnly":false,"decimalPlaces":2,"cellFormat":"number"}]},{"headerRow":false,"columns":[{"cellStyle":"defaultCellStyle","content":"<p>Sarcomere length</p>","headerColumn":true,"readOnly":true,"decimalPlaces":2,"cellFormat":"number"},{"cellStyle":"defaultCellStyle","content":"<p></p>","headerColumn":false,"readOnly":false,"decimalPlaces":2,"cellFormat":"number"},{"cellStyle":"defaultCellStyle","content":"<p>Resting 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Muscle</strong></p>","headerColumn":false,"originalColIndex":1,"originalRowIndex":0},{"cellStyle":"grayCellStyle","content":"<p><strong>Relaxed Muscle</strong></p>","headerColumn":false,"originalColIndex":2,"originalRowIndex":0},{"cellStyle":"grayCellStyle","content":"<p><strong>Contracted Muscle</strong></p>","headerColumn":false,"originalColIndex":3,"originalRowIndex":0}]},{"headerRow":false,"columns":[{"cellStyle":"defaultCellStyle","content":"<p>Extent of filament overlap</p>","headerColumn":true,"originalColIndex":0,"originalRowIndex":1},{"cellStyle":"defaultCellStyle","content":"<p>Little overlap</p>","headerColumn":false,"originalColIndex":1,"originalRowIndex":1},{"cellStyle":"defaultCellStyle","content":"<p>Some overlap</p>","headerColumn":false,"originalColIndex":2,"originalRowIndex":1},{"cellStyle":"defaultCellStyle","content":"<p>Plenty of 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Ca<sup>2&#43;</sup>-release channels called ryanodine receptors (RyRs) are embedded in the SR membrane.</p><p>L-type Ca<sup>2&#43;</sup> channels in the t-tubules are physically linked to RyRs in the SR, and activation of these channels directly activates the RyRs channels.</p><p>The SR membrane also contains an ATP-fueled pump called SERCA (sarcoendoplasmic reticulum calcium ATPase).</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"f6e64ae7-0520-4d2c-93a9-85e92e622431","revisionUuid":"2e9ee746-63ce-4bcc-9bf5-8e4f93475397"}],"16110":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"16110","dataValue":{"default":{"theText":"<p>You can examine this through electrical stimulation of the peripheral nerve.</p><ul><li>At low stimulus strengths, no motor nerves are depolarized and no muscle contraction is seen.</li><li>As stimulus strength is increased, some motor neurons are brought above their threshold potential and an action potential is fired. 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For example, in a peripheral nerve?</strong></p><p>The terms endomysium, perimysium, and epimysium may sound familiar if you have previously learned about peripheral nerve structure:</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"f3f2a6f6-78ab-4cbe-a8f5-d3fe2395abad","revisionUuid":"51c36b13-0444-4b51-a690-de5aad55cdad"}],"18648":[{"pluginKey":"image","typeKey":"content","dataKey":"18648","dataValue":{"default":{"imageResourceKey":"18746","caption":"","cropLeftOffset":0.0,"cropTopOffset":0.0,"cropWidthProportion":1.0,"presentedRatio":1.0820895522388059,"presentedSize":92.6689783839424,"rotationRadians":0.0,"flip":false,"copyrightText":""}},"dataVersion":2,"uuid":"68002cb1-3556-4b2b-ac83-2087ac20b2e7","revisionUuid":"27e5cfc6-e9ae-41e2-b1db-8c238b6e2771"}],"15461":[{"pluginKey":"page","typeKey":"content","dataKey":"15461","dataValue":{"default":{"title":"Motor units","rows":[{"cells":[{"panels":[{"pluginKey":"kcTextArea","dataKey":"15462","panelKey":"15463","columns":11}]},{"panels":[{"pluginKey":"button","dataKey":"16371","panelKey":"16372","columns":1}]}]},{"cells":[{"panels":[{"pluginKey":"divider","dataKey":"15464","panelKey":"15465","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"kcTextArea","dataKey":"15466","panelKey":"15467","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"divider","dataKey":"15470","panelKey":"15471","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"kcTextArea","dataKey":"15547","panelKey":"15548","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"kcTextArea","dataKey":"15549","panelKey":"15550","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"image","dataKey":"15553","panelKey":"15554","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"categories","dataKey":"15551","panelKey":"15552","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"divider","dataKey":"17259","panelKey":"17260","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"image","dataKey":"18027","panelKey":"18028","columns":2}]},{"panels":[{"pluginKey":"whitespace","dataKey":"19074","panelKey":"19075","columns":10},{"pluginKey":"kcTextArea","dataKey":"17246","panelKey":"17247","columns":10}]}]},{"cells":[{"panels":[{"pluginKey":"select","dataKey":"17254","panelKey":"17255","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"categories","dataKey":"17261","panelKey":"17262","columns":12}]}]}]}},"dataVersion":2,"uuid":"60f17d8d-25bb-49da-adbc-285d7505183e","revisionUuid":"1bd2d38a-9650-46a3-9944-2df4d01a5c12"}],"17761":[{"pluginKey":"popupPage","typeKey":"content","dataKey":"17761","dataValue":{"default":{"title":"Perimysium","rows":[],"shortDescription":"<p>The prefix peri- is derived from the Greek word <em>peri</em> meaning &#34;around&#34;. Remember that the <strong>peri</strong>mysium (which surrounds each bundle of muscle fibers) wraps <strong>around</strong> each fascicle. </p>"}},"dataVersion":2,"uuid":"3c497c5d-643b-4b4b-9e99-00783a4993d1","revisionUuid":"40396dba-2394-4398-9ea1-7975c7444e74"}],"17764":[{"pluginKey":"popupPage","typeKey":"content","dataKey":"17764","dataValue":{"default":{"title":"Troponin","rows":[],"shortDescription":"<p>Troponin is a protein associated with tropomyosin.</p>"}},"dataVersion":2,"uuid":"a954fbfa-9a76-4997-9914-300baa7815dd","revisionUuid":"bf743d7c-7652-432a-b5af-ee03a4d0fc3e"}],"16796":[{"pluginKey":"popupPage","typeKey":"content","dataKey":"16796","dataValue":{"default":{"title":"Eccentric","rows":[],"shortDescription":"<p>Eccentric comes from the Greek words <em>ek</em>, meaning &#34;out of&#34; and <em>kentron</em>, meaning &#34;center&#34;.</p>"}},"dataVersion":2,"uuid":"61fa4271-a087-4047-a3ff-d2e771e31c84","revisionUuid":"12bfcedd-13e9-4162-a478-bd736e4f1de5"}],"16795":[{"pluginKey":"popupPage","typeKey":"content","dataKey":"16795","dataValue":{"default":{"title":"Concentric","rows":[],"shortDescription":"<p>Concentric comes from the Latin words <em>con</em>-, meaning &#34;together&#34; and <em>centrum</em>, meaning &#34;center&#34;.</p>"}},"dataVersion":2,"uuid":"939d6dba-53a0-45ad-9a2c-34f0713c9725","revisionUuid":"cfe796da-120d-4d8b-82f0-fa2045bcf335"}],"15464":[{"pluginKey":"divider","typeKey":"content","dataKey":"15464","dataValue":{"default":{"placeholder":null}},"dataVersion":1,"uuid":"595d33ad-f0f1-442a-9aae-42bc027f4aa9","revisionUuid":"b1456898-28ba-4eb2-9cfb-a1c0fdf12c9a"}],"16311":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"16311","dataValue":{"default":{"theText":"<p><strong>Words of wisdom from the <a data-popupkey=\"16321\" rel=\"nofollow\" target=\"_blank\">experts</a> who study the science of learning:</strong></p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"650e738e-c0f6-40eb-8f77-3bf3adf91906","revisionUuid":"9da90274-b2d5-45b2-89f0-5cff0b86d493"}],"15462":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"15462","dataValue":{"default":{"theText":"<h1>Motor units</h1>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"1941383b-af50-46b4-9f26-9ead3ad67d4a","revisionUuid":"8c81f59d-8dca-4f8d-a5d6-85130bed0132"}],"16315":[{"pluginKey":"image","typeKey":"content","dataKey":"16315","dataValue":{"default":{"imageResourceKey":"16341","caption":"<p>Elaborate on what you know.<br />Describe new topics in your own words. </p>","cropLeftOffset":0.0,"cropTopOffset":0.0,"cropWidthProportion":1.0,"presentedRatio":0.9473684210526315,"presentedSize":30.31156156156156,"rotationRadians":0.0,"flip":false,"copyrightText":""}},"dataVersion":2,"uuid":"cd855568-b9e9-4264-b136-b50183f766f1","revisionUuid":"7932a5b9-2046-4e4e-8e75-b475dd7f373f"}],"15466":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"15466","dataValue":{"default":{"theText":"<p><strong>What is the relationship between nerves and muscle fibers?</strong></p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"57aa8394-0dfa-47d6-9452-7b75e763f68c","revisionUuid":"e3c85972-07a5-40a4-8aa9-d6d63868ad39"}],"16313":[{"pluginKey":"image","typeKey":"content","dataKey":"16313","dataValue":{"default":{"imageResourceKey":"16340","caption":"<p>Don&#39;t assume you understand – prove it! Quiz yourself often.</p>","cropLeftOffset":0.0,"cropTopOffset":0.0,"cropWidthProportion":1.0,"presentedRatio":0.9006849315068494,"presentedSize":31.882643099373137,"rotationRadians":0.0,"flip":false,"copyrightText":""}},"dataVersion":2,"uuid":"cfa4cba0-7ce8-466d-9fc4-6ffd49374709","revisionUuid":"1da76db5-ac32-457c-9872-23f64bcc9368"}],"14812":[{"pluginKey":"popupPage","typeKey":"content","dataKey":"14812","dataValue":{"default":{"title":"Learning objectives","rows":[{"cells":[{"panels":[{"pluginKey":"kcTextArea","dataKey":"14813","panelKey":"14814","columns":12}]}]}],"shortDescription":""}},"dataVersion":2,"uuid":"ce1bf01e-d198-4c86-b47c-f44fb59db411","revisionUuid":"23ff3725-d4ce-4876-9a46-0ef1579b9daa"}],"17765":[{"pluginKey":"image","typeKey":"content","dataKey":"17765","dataValue":{"default":{"imageResourceKey":"12188","caption":"","cropLeftOffset":0.0,"cropTopOffset":0.0,"cropWidthProportion":1.0,"presentedRatio":0.6491803278688525,"presentedSize":100.0,"rotationRadians":0.0,"flip":false,"copyrightText":"Painting by Sir Charles Bell, courtesy of Wikimedia Commons. Available in the public domain. "}},"dataVersion":2,"uuid":"5c10abcb-1625-4f39-8827-e6379ee21016","revisionUuid":"75ee32a7-d3a0-4996-a91e-3271069c079b"}],"14813":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"14813","dataValue":{"default":{"theText":"<h3>Learning objectives</h3><p>By the end of this lesson you will be able to do the following:</p><ul><li>Describe the structure and function of skeletal muscle.</li><li>Explain the organization of a myofibril, including the transverse (T) tubules and sarcoplasmic reticulum.</li><li>Identify and describe the function of the contractile, regulatory, and structural protein components of a sarcomere.</li><li>Describe the anatomy of the neuromuscular junction (NMJ).</li><li>Order the events that occur at the NMJ to elicit an action potential in the muscle fiber.</li><li>Explain what is meant by the expression &#34;excitation-contraction coupling&#34;.</li><li>Describe the sequence of events involved in the crossbridge cycle.</li><li>Explain the sliding filament theory of muscle contraction.</li><li>Describe the difference between muscle twitch, summation, incomplete tetanus, and tetanus.</li><li>Explain the differences between isometric and isotonic contractions.</li></ul><p>You can use these to guide your study.</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"78e53920-76cc-4f0d-adf4-d74d93141280","revisionUuid":"455a2857-83b0-4ff6-a9da-334738ee0aeb"}],"16317":[{"pluginKey":"image","typeKey":"content","dataKey":"16317","dataValue":{"default":{"imageResourceKey":"16342","caption":"<p>Space out your learning, and<br />remember to repeat! </p>","cropLeftOffset":0.0,"cropTopOffset":0.0,"cropWidthProportion":1.0,"presentedRatio":0.91015625,"presentedSize":31.55086416888992,"rotationRadians":0.0,"flip":false,"copyrightText":""}},"dataVersion":2,"uuid":"8536ff14-2a52-47a1-8fe3-976c503a5196","revisionUuid":"22589b21-94f8-42e0-b1b1-4a277f8c36c5"}],"16561":[{"pluginKey":"scope","typeKey":"content","dataKey":"16561","dataValue":{"default":{"dataResourceKey":"16610"}},"dataVersion":1,"uuid":"879b49e2-d112-440d-8188-19804444dcb7","revisionUuid":"b063ae15-534e-41ff-a4ce-f22b68214216"}],"15470":[{"pluginKey":"divider","typeKey":"content","dataKey":"15470","dataValue":{"default":{"placeholder":null}},"dataVersion":1,"uuid":"50b6c113-3aa8-428c-88ab-5e3a92f6cd1b","revisionUuid":"53635680-2ede-45de-951f-0aeeaf2cf4ea"}],"lessonMetaData":[{"pluginKey":"lessonMetaData","typeKey":"content","dataKey":"lessonMetaData","dataValue":{"default":{"title":"Skeletal Muscle Structure and Function","description":"v1.3.1 (en-US) Bioscience tutorials, Human Physiology, Preclinical Medicine, Immersive Nursing, Neuroscience, Psychophysiology, No recording devices","groupLesson":false,"presentation":false,"keywords":"musculoskeletal, skeletal muscle, motor unit, t-tubules, sarcomere, neuromuscular junction, excitation-contraction coupling, crossbridge cycle, sliding filament theory, twitch, summation, tetanus, isometric contraction, isotonic contraction","thumbnailResourceKey":"14357","instructorMaterial":{"instructorMaterialResourceKey":"19699","instructorMaterialFilename":"Skeletal Muscle Structure and Function – Lt Bioscience Instructor's Material.pdf"},"exportDrmProtection":null}},"dataVersion":6,"uuid":null,"revisionUuid":null}],"16564":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"16564","dataValue":{"default":{"theText":"<p>Shown below is example data of electrical activity (EMG) and force of contraction recorded during a twitch response. Move through <a data-popupkey=\"19184\" rel=\"nofollow\" target=\"_blank\">records</a> 1–3 to see how the EMG and force of the twitch response changes as <a data-popupkey=\"18168\" rel=\"nofollow\" target=\"_blank\">stimulus</a> strength (mA) is increased.</p><p>Use this data to answer the questions that follow.</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"b29d5cf5-9275-4408-8a4f-ae290cf8715a","revisionUuid":"b23ba418-daa8-40d0-8db1-a1a1b8fe7ef7"}],"16322":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"16322","dataValue":{"default":{"theText":"<h3>References</h3><p>[1] Brown, P. C., Roediger, H. L., &amp; McDaniel, M. A. (2014). <em>Make it stick: the science of successful learning</em>. Cambridge, MA: The Belknap Press of Harvard University Press.</p><p>[2] Medina, J. (2014). <em>Brain rules: 12 principles for surviving and thriving at work, home and school</em>. Seattle: Pear press.</p><p>[3] McGuire, S. Y., McGuire, S., &amp; Angelo, T. A. (2015). <em>Teach students how to learn: strategies you can incorporate into any course to improve student metacognition, study skills, and motivation</em>. Sterling: Stylus Publishing.</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"84ea9f5d-27b4-45f2-b654-510301c478b1","revisionUuid":"61f79eb6-8b58-47fc-b287-df272a81880a"}],"16321":[{"pluginKey":"popupPage","typeKey":"content","dataKey":"16321","dataValue":{"default":{"title":"References","rows":[{"cells":[{"panels":[{"pluginKey":"kcTextArea","dataKey":"16322","panelKey":"16323","columns":12}]}]}],"shortDescription":""}},"dataVersion":2,"uuid":"6d1d3914-ff6b-4cc4-a92b-180b7c121ec3","revisionUuid":"7a440067-ad40-423e-bdb8-c74bdc01943e"}],"17771":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"17771","dataValue":{"default":{"theText":"<p>Tetanus is a state of sustained muscle contraction. It is also an infectious disease caused by the neurotoxin tetanospasmin<em> </em>and is characterized by widespread tetanic skeletal muscle contractions. There is a high mortality rate associated with tetanus (over 50%), but the symptoms may be treated by medical professionals with muscle relaxants, which vastly improve the patient&#39;s likelihood of full recovery.</p><p>Tetanus is the focus of a famous artwork painted by Sir Charles Bell in 1809. The painting depicts a warrior suffering tetanus. The man&#39;s muscles are in a state of sustained contraction, pulling him into the classic &#34;bow shape&#34; that many people succumb to while suffering tetanus.</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"fcbc6b03-d499-42fa-9483-57f2759fa276","revisionUuid":"2d05883c-623c-444c-a415-0155b6718f5f"}],"16562":[{"pluginKey":"scope","typeKey":"presentation","dataKey":"16562","dataValue":{"height":360,"channelValues":[],"timeCalculation":false,"timeUnit":"auto"},"dataVersion":2,"uuid":"88ed56d4-c3a2-4190-abfc-9800d571b830","revisionUuid":"2be82be8-dc3f-47a5-9181-b5055e3bfd58"}],"17417":[{"pluginKey":"table","typeKey":"content","dataKey":"17417","dataValue":{"default":{"rows":[{"headerRow":true,"columns":[{"cellStyle":"grayCellStyle","content":"<p><strong>Skeletal Muscle</strong></p>","headerColumn":false,"decimalPlaces":2,"cellFormat":"number"},{"cellStyle":"grayCellStyle","content":"<p><strong>Peripheral Nerve</strong></p>","headerColumn":false,"decimalPlaces":2,"cellFormat":"number"}]},{"headerRow":false,"columns":[{"cellStyle":"defaultCellStyle","content":"<p><strong>Endomysium</strong>: surrounds each individual muscle fiber.</p>","headerColumn":false,"decimalPlaces":2,"cellFormat":"number"},{"cellStyle":"defaultCellStyle","content":"<p><strong>Endoneurium</strong>: surrounds each individual nerve fiber.</p>","headerColumn":false,"decimalPlaces":2,"cellFormat":"number"}]},{"headerRow":false,"columns":[{"cellStyle":"defaultCellStyle","content":"<p><strong>Perimysium</strong>: surrounds each fascicle (bundle of muscle fibers).</p>","headerColumn":false,"decimalPlaces":2,"cellFormat":"number"},{"cellStyle":"defaultCellStyle","content":"<p><strong>Perineurium</strong>: surrounds each fascicle (bundle of nerve fibers).</p>","headerColumn":false,"decimalPlaces":2,"cellFormat":"number"}]},{"headerRow":false,"columns":[{"cellStyle":"defaultCellStyle","content":"<p><strong>Epimysium</strong>: surrounds an entire muscle.</p>","headerColumn":false,"decimalPlaces":2,"cellFormat":"number"},{"cellStyle":"defaultCellStyle","content":"<p><strong>Epineurium</strong>: surrounds an entire nerve.</p>","headerColumn":false,"decimalPlaces":2,"cellFormat":"number"}]}],"columnWidths":[0.5034722004161643,0.49652779958383575]}},"dataVersion":2,"uuid":"a00cbeb7-2bb8-4a6e-871e-08535d19eda0","revisionUuid":"c785726a-2b69-42e4-bd3e-559244b37d2f"}],"15598":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"15598","dataValue":{"default":{"theText":"<p><strong>What is the neuromuscular junction? 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When he was young, his teacher would often correct his posture by saying, &#34;Shoulders back!&#34;. He also had to learn how to reduce the force with which he moved his fingers, so that he did not &#34;bang&#34; on the keys. How does Steve control his muscles for good posture and smooth finger movements?</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"7eb2e532-0165-4bb9-ab80-d9de6e9708e3","revisionUuid":"45976810-a281-47e2-ac0d-71a4a0bbc312"}],"17862":[{"pluginKey":"drag-and-drop","typeKey":"presentation","dataKey":"17862","dataValue":{"imageSize":100.0},"dataVersion":5,"uuid":"90149309-b13f-4f6b-9dbf-7a8e5619f605","revisionUuid":"7c04d235-707e-49ae-b481-2990946ef317"}],"16531":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"16531","dataValue":{"default":{"theText":"<p>Step 3: <strong>P<sub>i</sub> dissociates from myosin; new crossbridge forms</strong>. P<sub>i</sub> dissociates from the myosin head, which allows myosin to bind with high affinity to actin [<a data-popupkey=\"15927\" rel=\"nofollow\" target=\"_blank\"><strong>&#43;</strong></a>]. That is, a new crossbridge is formed. At this stage, ADP is still attached to myosin.</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"1950d180-6a8d-47c8-88f3-1083a1b5d18a","revisionUuid":"b1a62e38-ec12-4fc1-b6b2-c47a807a2e13"}],"16893":[{"pluginKey":"select","typeKey":"modelAnswer","dataKey":"16893","dataValue":{"default":{"answers":[{"answerDescription":"<p>The removal of released calcium causes the muscle to relax as it inhibits actin-myosin crossbridge formation.</p>","checked":true},{"answerDescription":"<p>Potassium does not directly affect the tropomyosin or troponin complex that plays a role in the powerstroke action of skeletal muscle contractions. </p>","checked":false},{"answerDescription":"<p>Sodium does not directly affect the tropomyosin or troponin complex that plays a role in the powerstroke action of skeletal muscle contractions. </p>","checked":false}]}},"dataVersion":1,"uuid":"914325bd-7f77-4a1f-b0c9-a9ca6ce32d39","revisionUuid":"68e0d08f-f11d-4415-97f1-278e56ffec93"},{"pluginKey":"select","typeKey":"content","dataKey":"16893","dataValue":{"default":{"question":"<p>The removal of which ion causes the muscle to relax after contraction?</p>","multiselect":false,"answers":[{"answer":"<p>Ca<sup>2&#43;</sup></p>"},{"answer":"<p>K<sup>&#43;</sup></p>"},{"answer":"<p>Na<sup>&#43;</sup></p>"}],"singleAttempt":false,"assessmentType":"instantFeedback","maximumGrade":1.0}},"dataVersion":2,"uuid":"914325bd-7f77-4a1f-b0c9-a9ca6ce32d39","revisionUuid":"68e0d08f-f11d-4415-97f1-278e56ffec93"}],"15320":[{"pluginKey":"page","typeKey":"content","dataKey":"15320","dataValue":{"default":{"title":"Skeletal muscle organization","rows":[{"cells":[{"panels":[{"pluginKey":"kcTextArea","dataKey":"15323","panelKey":"15324","columns":10}]},{"panels":[{"pluginKey":"button","dataKey":"16369","panelKey":"16370","columns":2}]}]},{"cells":[{"panels":[{"pluginKey":"divider","dataKey":"15325","panelKey":"15326","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"kcTextArea","dataKey":"15329","panelKey":"15330","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"divider","dataKey":"15327","panelKey":"15328","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"kcTextArea","dataKey":"15545","panelKey":"15546","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"kcTextArea","dataKey":"15422","panelKey":"15423","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"drag-and-drop","dataKey":"15415","panelKey":"15416","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"select","dataKey":"17117","panelKey":"17118","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"divider","dataKey":"15459","panelKey":"15460","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"kcTextArea","dataKey":"15425","panelKey":"15426","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"kcTextArea","dataKey":"15454","panelKey":"15455","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"categories","dataKey":"15537","panelKey":"15538","columns":12}]}]}]}},"dataVersion":2,"uuid":"2ca58a4c-b8df-457d-8ce8-61d3f350afb6","revisionUuid":"33929050-ec2b-4d39-9e4a-7467a67b1a02"}],"12175":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"12175","dataValue":{"default":{"theText":"<h3>Well done! You&#39;ve completed this lesson on Skeletal Muscle Structure and Function.</h3>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"6b1db5af-5a3a-4f13-a1b3-35bcc3cfc6ad","revisionUuid":"25c045ce-594c-4771-8da9-074e894c5e90"}],"12858":[{"pluginKey":"image","typeKey":"content","dataKey":"12858","dataValue":{"default":{"imageResourceKey":"18619","caption":"<p></p>","cropLeftOffset":0.0,"cropTopOffset":0.0,"cropWidthProportion":1.0,"presentedRatio":0.7712765957446809,"presentedSize":100.0,"rotationRadians":0.0,"flip":false,"copyrightText":""}},"dataVersion":2,"uuid":"276a96dd-4343-436d-8d1b-996f3722a029","revisionUuid":"b0e929c7-54f6-4eb2-a2a2-43fe5b00134f"}],"16414":[{"pluginKey":"popupPage","typeKey":"content","dataKey":"16414","dataValue":{"default":{"title":"Questions (original)","rows":[{"cells":[{"panels":[{"pluginKey":"kcTextArea","dataKey":"16418","panelKey":"16419","columns":12}]}]},{"cells":[{"panels":[{"pluginKey":"select","dataKey":"15304","panelKey":"16417","columns":12}]}]}],"shortDescription":""}},"dataVersion":2,"uuid":"6411ce78-4464-44f2-abbc-e9785b4f69b6","revisionUuid":"e892ae40-7458-4e9f-abd1-0124b21251b6"}],"15325":[{"pluginKey":"divider","typeKey":"content","dataKey":"15325","dataValue":{"default":{"placeholder":null}},"dataVersion":1,"uuid":"bf8164ef-0ba1-4113-9703-d92b2aa4a6a0","revisionUuid":"6dcefe99-8119-44ca-8380-c36a973e4953"}],"17869":[{"pluginKey":"divider","typeKey":"content","dataKey":"17869","dataValue":{"default":{"placeholder":null}},"dataVersion":1,"uuid":"d985a98d-d349-4f10-bd52-0853cf655d27","revisionUuid":"d835d3a1-dc30-445b-aa3d-b896f5156a84"}],"16897":[{"pluginKey":"select","typeKey":"modelAnswer","dataKey":"16897","dataValue":{"default":{"answers":[{"answerDescription":"<p>While this is the protein complex that enables muscular contraction, it is contained within a organizational unit.</p>","checked":false},{"answerDescription":"<p>This is a few levels of organization up from the functional unit of muscle fibers.</p>","checked":false},{"answerDescription":"<p>This is a level of organization up from the functional unit of muscle fibers.</p>","checked":false},{"answerDescription":"<p>Sarcomeres are organized within the myofibrils of skeletal muscle cells. They contain actin and myosin proteins which are involved in contraction.</p>","checked":true}]}},"dataVersion":1,"uuid":"8d3d4bc5-d066-4851-8622-a0a456a02511","revisionUuid":"1d7ba729-5ff0-46be-b142-0e1ffc77babd"},{"pluginKey":"select","typeKey":"content","dataKey":"16897","dataValue":{"default":{"question":"<p>What is the functional unit of a skeletal muscle fiber?</p>","multiselect":false,"answers":[{"answer":"<p>Actin-myosin complex</p>"},{"answer":"<p>Fascicle</p>"},{"answer":"<p>Myofibril</p>"},{"answer":"<p>Sarcomere</p>"}],"singleAttempt":false,"assessmentType":"instantFeedback","maximumGrade":1.0}},"dataVersion":2,"uuid":"8d3d4bc5-d066-4851-8622-a0a456a02511","revisionUuid":"1d7ba729-5ff0-46be-b142-0e1ffc77babd"}],"15566":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"15566","dataValue":{"default":{"theText":"<h1>Neuromuscular junction</h1>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"98d3d11b-4794-4868-af1c-b773f891fc51","revisionUuid":"5e666681-752e-48cc-b751-1ce68d636b7c"}],"16412":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"16412","dataValue":{"default":{"theText":"<p>At the beginning of this lesson you were asked <a data-popupkey=\"16414\" rel=\"nofollow\" target=\"_blank\">these questions</a>. How do you feel about them now?</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"be3e2ef1-b261-4de1-a414-eb8e32d1aec5","revisionUuid":"0dd53151-e3e0-47e9-80a3-09d52a0df916"}],"15323":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"15323","dataValue":{"default":{"theText":"<h1>Skeletal muscle organization</h1>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"93aa9401-0745-4d53-80b8-5a5a44428588","revisionUuid":"0983c356-890d-44fb-a428-0abb8fea3268"}],"16539":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"16539","dataValue":{"default":{"theText":"<p>Step 4: <strong>Powerstroke occurs; muscle shortens</strong>. The myosin neck rotates around the myosin head which is attached to actin. This bending action results in a &#34;powerstroke&#34; where myosin pulls actin closer to the center of the sarcomere. The muscle shortens and force is generated in the muscle.</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"1de634fa-4205-4b60-b9d2-358ea842aad8","revisionUuid":"bccc0c31-9baa-40b6-b360-0cdf43663601"}],"15329":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"15329","dataValue":{"default":{"theText":"<p>The question here is: <strong>How are the components of skeletal muscle arranged? </strong></p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"4d35ea8b-890f-4b97-b4d8-628bc963c2f9","revisionUuid":"05367c84-e231-4907-a867-112f121daf1d"}],"17865":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"17865","dataValue":{"default":{"theText":"<h3>Try it yourself!</h3><h3><sub>Isotonic contraction</sub></h3><ul><li>Hold a heavy book in your hand with your arm straight out and palm turned upwards.</li><li>While still holding the book, do a slow bicep curl up to your shoulder.</li></ul><p>In this situation, the biceps brachii muscle contracts <a data-popupkey=\"12021\" rel=\"nofollow\" target=\"_blank\">concentrically</a> to lift the weight. At the same time, the triceps brachii contracts <a data-popupkey=\"12022\" rel=\"nofollow\" target=\"_blank\">eccentrically</a> to help control this lifting movement.</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"69d7de0d-0b13-4a89-adf1-ce5f0ed33976","revisionUuid":"0e59e5bd-fb77-4d8e-8da2-a7d4a5605d76"}],"16418":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"16418","dataValue":{"default":{"theText":"<p>Shown below are your answers to the questions at the beginning of the lesson.</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"5e81fd0c-12f4-4775-9e48-88acd8754918","revisionUuid":"d888eba9-705e-4999-bbd2-dedec9cfa749"}],"12855":[{"pluginKey":"image","typeKey":"content","dataKey":"12855","dataValue":{"default":{"imageResourceKey":"18621","caption":"<p></p>","cropLeftOffset":0.0,"cropTopOffset":0.0,"cropWidthProportion":1.0,"presentedRatio":0.7712765957446809,"presentedSize":100.0,"rotationRadians":0.0,"flip":false,"copyrightText":""}},"dataVersion":2,"uuid":"5e383afd-1533-4d12-a75e-044d0b9077f4","revisionUuid":"c8c839e8-2886-4913-ad78-c7da3ffd6f2e"}],"15449":[{"pluginKey":"popupPage","typeKey":"content","dataKey":"15449","dataValue":{"default":{"title":"Question: Connective tissue layers","rows":[{"cells":[{"panels":[{"pluginKey":"kcTextArea","dataKey":"15450","panelKey":"15451","columns":12}]}]}],"shortDescription":"Why is the epimysium much tougher than the endomysium?"}},"dataVersion":2,"uuid":"cad9d899-0116-4501-9fb1-77b5a4290aee","revisionUuid":"28490ce8-3449-415a-b520-79a4c0005652"}],"10556":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"10556","dataValue":{"default":{"theText":"<h1>Lesson reflection</h1>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"1dc7f396-abca-40ce-8266-af3ad0b8766a","revisionUuid":"e2a513d8-cc82-49b7-91a1-616edaebe0cf"}],"17867":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"17867","dataValue":{"default":{"theText":"<h3> </h3><h3><sub>Isometric contraction</sub></h3><ul><li>Hold something heavy in your hands (like a book or a laptop).</li><li>Extend your arms straight out in front of you and hold this position. </li></ul><p>To overcome gravity, the muscles have to contract to maintain that position but muscle length is unchanged [<a data-popupkey=\"16855\" rel=\"nofollow\" target=\"_blank\"><strong>&#43;</strong></a>]. </p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"ee5adebc-67a5-4ce3-83c3-f03b3d795a6e","revisionUuid":"2af36965-d07b-43a9-b9e7-d9ac7c32a770"}],"15327":[{"pluginKey":"divider","typeKey":"content","dataKey":"15327","dataValue":{"default":{"placeholder":null}},"dataVersion":1,"uuid":"c568b322-ced1-40ff-8335-b7ae5014d72b","revisionUuid":"0313f3c3-f8aa-49c5-bf2c-38959f5ddfdf"}],"15450":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"15450","dataValue":{"default":{"theText":"<p><strong>Why is the epimysium much tougher than the endomysium? </strong></p><p>The epimysium, perimysium, and endomysium are layers of connective tissue that help to protect the muscle. While the endomysium is delicate, the epimysium is tougher and more resistant to tears.</p><p>The epimysium must be tough to reduce friction with other muscles and bones. There are additional layers of connective tissue that surround the muscle (for example, deep fascia) which further protect the muscle.</p><p>In contrast, the endomysium is a delicate layer of connective tissue that helps regulate the chemical environment around each nerve fiber.</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"7fe8a418-d598-4a36-b400-77765ae9aea4","revisionUuid":"5700806b-06b8-4ef4-bf47-61e51a0a51f7"}],"18168":[{"pluginKey":"popupPage","typeKey":"content","dataKey":"18168","dataValue":{"default":{"title":"Stimulus","rows":[],"shortDescription":"Note that the delivery of the stimulus is indicated by the comment (for example, 5 mA)."}},"dataVersion":2,"uuid":"5d4d2fef-220e-4df4-a663-30a3ed11f70f","revisionUuid":"3a27f60c-d61c-4a10-bb98-b47285246de4"}],"12181":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"12181","dataValue":{"default":{"theText":"<h3>Tetanus</h3>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"b3bcc060-2816-4c8f-bd30-d6a63eda2f03","revisionUuid":"bfb8ec39-f558-402f-9f79-3b8db0e1cdaf"}],"16422":[{"pluginKey":"divider","typeKey":"content","dataKey":"16422","dataValue":{"default":{"placeholder":null}},"dataVersion":1,"uuid":"a1438a73-c8eb-4d49-b916-0f04a222eb0d","revisionUuid":"afc3a025-55a6-4dc0-b3c0-bf310f5d9b08"}],"16301":[{"pluginKey":"divider","typeKey":"content","dataKey":"16301","dataValue":{"default":{"placeholder":null}},"dataVersion":1,"uuid":"67db442f-fbcc-46dc-9bbc-05cc24b3af4a","revisionUuid":"9b9e10ec-28c1-4f47-99ce-3ca011f68e1f"}],"16543":[{"pluginKey":"image","typeKey":"content","dataKey":"16543","dataValue":{"default":{"imageResourceKey":"18622","caption":"","cropLeftOffset":0.0,"cropTopOffset":0.0,"cropWidthProportion":1.0,"presentedRatio":0.7712765957446809,"presentedSize":100.0,"rotationRadians":0.0,"flip":false,"copyrightText":""}},"dataVersion":2,"uuid":"1bde91d8-193d-42ad-8b05-c12f17869e2d","revisionUuid":"342636c4-c452-4fb0-ae3e-72f8d006ee89"}],"19133":[{"pluginKey":"drag-and-drop","typeKey":"presentation","dataKey":"19133","dataValue":{"imageSize":100.0},"dataVersion":5,"uuid":"973bce33-21f5-4ba5-ac15-5e37d2a8e6d2","revisionUuid":"7717849d-bd55-4d88-8811-dc63ad06ba43"}],"15454":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"15454","dataValue":{"default":{"theText":"<p>The properties of each muscle cell facilitate its functions.</p><ul><li><strong>Contractile</strong>; it has the ability to shorten in response to adequate electrical stimulation.</li><li><strong>Elastic</strong>; it has the ability to recoil and regain the resting length after being stretched.</li><li><strong>Excitable</strong>; it has the ability to receive and respond to a stimulus.</li><li><strong>Extensible</strong>; it has the ability to stretch when not contracted.</li></ul>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"35a9edf0-c91c-4d42-9393-2ee10c07cf7c","revisionUuid":"e06313ea-050a-4929-bce6-ea7e350ff148"}],"19132":[{"pluginKey":"drag-and-drop","typeKey":"content","dataKey":"19132","dataValue":{"default":{"question":"<p>Arrange events at the NMJ and afterwards, in the order in which they occur.</p>","imageResourceKey":"16259","imageRatio":1.0,"labelItems":[{"label":"<p>ACh binds to nicotinic receptors on the motor endplate.</p>","leftProportion":-0.02564102564102564,"topProportion":0.14125664490985845},{"label":"<p>Depolarization of muscle cell membrane.</p>","leftProportion":0.0,"topProportion":0.28785756941200386},{"label":"<p>Local depolarization of the motor endplate.</p>","leftProportion":-0.021367521367521368,"topProportion":0.43272197729592715},{"label":"<p>Muscle contraction.</p>","leftProportion":-0.027777777777777776,"topProportion":0.5752061598152185},{"label":"<p>Cation-selective ion channels open in the motor endplate.</p>","leftProportion":0.0,"topProportion":0.7187083003520882},{"label":"<p>Raised intracellular Ca<sup>2&#43;</sup> concentration.</p>","leftProportion":-0.022435897435897436,"topProportion":0.8593362064863835}],"labelLocationItems":[{"leftProportion":0.5571581196581197,"topProportion":0.14407099942904597},{"leftProportion":0.5572081997863247,"topProportion":0.2886210379251877},{"leftProportion":0.5566740117521367,"topProportion":0.4316740793366552},{"leftProportion":0.5576088408119658,"topProportion":0.5725115650628049},{"leftProportion":0.5565070779914529,"topProportion":0.7170017236755597},{"leftProportion":0.5567073985042735,"topProportion":0.8577194496349354}],"labelListPosition":"outside-topLeft","copyrightText":"","labelWidthProportion":0.431937296652842,"labelHeightProportion":0.12399355187166045,"presentedRatio":0.5575620767494357,"singleAttempt":false,"assessmentType":"instantFeedback","maximumGrade":1.0}},"dataVersion":6,"uuid":"116f4012-470b-4978-a3e5-cd1e73321371","revisionUuid":"da6ddfaf-e07f-433a-8049-91c315c5ba5c"},{"pluginKey":"drag-and-drop","typeKey":"modelAnswer","dataKey":"19132","dataValue":{"default":{"linkedLabels":[{"labelIndex":3,"locationIndex":5},{"labelIndex":0,"locationIndex":0},{"labelIndex":4,"locationIndex":1},{"labelIndex":2,"locationIndex":2},{"labelIndex":5,"locationIndex":4},{"labelIndex":1,"locationIndex":3}],"feedbackText":""}},"dataVersion":5,"uuid":"116f4012-470b-4978-a3e5-cd1e73321371","revisionUuid":"da6ddfaf-e07f-433a-8049-91c315c5ba5c"}],"16541":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"16541","dataValue":{"default":{"theText":"<p>Step 5: <strong>ADP dissociates from myosin; myosin awaits another ATP molecule</strong>. ADP dissociates from myosin, but actin and myosin remain attached and in a rigid state. Another ATP molecule is required to break the link between actin and myosin, and for another crossbridge cycle to start.</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"73d3ac0c-e3d3-49db-8c49-da9230ebf7d3","revisionUuid":"5d434e05-de4a-42ef-9f52-2a05622f6317"}],"16420":[{"pluginKey":"select","typeKey":"content","dataKey":"16420","dataValue":{"default":{"question":"<ul><li>How is a skeletal muscle structured?</li><li>How does an electrical impulse from a nerve lead to muscle contraction?</li><li>How does a skeletal muscle contract and generate force?</li><li>How do skeletal muscle contractions differ?</li></ul>","multiselect":false,"answers":[{"answer":"<p>I could explain these in detail.</p>"},{"answer":"<p>I could describe the basic processes or principles.</p>"},{"answer":"<p>I could not adequately answer these questions.</p>"}],"singleAttempt":false,"assessmentType":"noAssessment","maximumGrade":1.0}},"dataVersion":2,"uuid":"4d6791ba-cc4a-44b4-b611-1dc474dc68e4","revisionUuid":"1aa7633c-5786-46ec-ab91-a7699bf8a55c"},{"pluginKey":"select","typeKey":"modelAnswer","dataKey":"16420","dataValue":{"default":{"answers":[{"answerDescription":"<p></p>","checked":false},{"answerDescription":"<p></p>","checked":false},{"answerDescription":"<p></p>","checked":false}]}},"dataVersion":1,"uuid":"4d6791ba-cc4a-44b4-b611-1dc474dc68e4","revisionUuid":"1aa7633c-5786-46ec-ab91-a7699bf8a55c"}],"12861":[{"pluginKey":"image","typeKey":"content","dataKey":"12861","dataValue":{"default":{"imageResourceKey":"18623","caption":"<p></p>","cropLeftOffset":0.0,"cropTopOffset":0.0,"cropWidthProportion":1.0,"presentedRatio":0.7712765957446809,"presentedSize":100.0,"rotationRadians":0.0,"flip":false,"copyrightText":""}},"dataVersion":2,"uuid":"17e0bac4-d770-43b0-9bd5-1ad299ee86e3","revisionUuid":"b4f93644-8245-4185-9eb1-e8da179d8ffa"}],"16305":[{"pluginKey":"image","typeKey":"content","dataKey":"16305","dataValue":{"default":{"imageResourceKey":"16319","caption":"","cropLeftOffset":8.803396629314388,"cropTopOffset":0.0,"cropWidthProportion":0.8171567698095131,"presentedRatio":0.6155860437252011,"presentedSize":100.0,"rotationRadians":0.0,"flip":false,"copyrightText":""}},"dataVersion":2,"uuid":"7ab37866-2145-4c46-a4be-ef23d0a8213a","revisionUuid":"e7bbd213-e0d1-45ff-af45-2197ef4be0df"}],"16303":[{"pluginKey":"kcTextArea","typeKey":"content","dataKey":"16303","dataValue":{"default":{"theText":"<h3>Put down the highlighter! </h3><p>Although rereading and highlighting text may feel productive, it&#39;s actually not. These techniques help you become more fluent with the material, but not master it <a data-popupkey=\"16321\" rel=\"nofollow\" target=\"_blank\"><sup>[1]</sup></a>. If you stop reviewing the material, it will soon be lost from your short-term memory! For learning to be durable and long lasting, you have to strengthen the neural pathways involved in retrieving the new information through asking questions, elaborating on the material, and reflecting <a data-popupkey=\"16321\" rel=\"nofollow\" target=\"_blank\"><sup>[1, 2, 3]</sup></a>.</p>","boxStyle":"defaultStyle","scrollable":false,"height":0}},"dataVersion":1,"uuid":"fdff8c32-3f44-47a3-9a25-4b2e94844b17","revisionUuid":"c68ce581-f7b0-4eb9-89eb-4baefff3c040"}],"16309":[{"pluginKey":"whitespace","typeKey":"content","dataKey":"16309","dataValue":{"default":{"height":30}},"dataVersion":1,"uuid":"9504e50e-84c6-4ff4-b438-b3c7ffae2d84","revisionUuid":"f918e1f3-5138-402b-bd2a-750680f7d298"}],"14800":[{"pluginKey":"divider","typeKey":"content","dataKey":"14800","dataValue":{"default":{"placeholder":null}},"dataVersion":1,"uuid":"510e4912-5848-484b-b762-3eb800bfc670","revisionUuid":"694e5824-9971-4239-8a3a-81e408691c67"}],"15459":[{"pluginKey":"divider","typeKey":"content","dataKey":"15459","dataValue":{"default":{"placeholder":null}},"dataVersion":1,"uuid":"72976420-5f3f-41c8-a309-d1b1eb919190","revisionUuid":"7296c506-a6e6-4aeb-b678-b6f65bdea07e"}]}}